Cissus Quadrangularis Clinical Evidence

 Lipids in Health and Disease

 Oben JE et al. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. 2007 Feb 4; 6:4.

 Topic:
How do Cissus quadrangularis (CQ) and a proprietary form of the plant perform when used for weight loss and improvement of cardiovascular health markers?

Background:
Obesity is associated with dysfunction in lipid metabolism and oxidative stress. Can CQ, a member of the grape family native to India and Sri Lanka, improve these markers?

Study Type:
Human clinical intervention trial

Study Design:
Double-blind, placebo-controlled. Researchers tested the antioxidant capacity of each substance in vitro in the first phase of the study. Next, subjects took CQ-300, CORE, or a placebo and researchers measured their body weight, body fat, lipids, and fasting blood sugar levels. 

Dosage:
300 mg (CQ-300) or 1,028 mg (CORE)/day in 2 doses

Subjects:
168 overweight and obese subjects, ages 19–54, 153 completed

Results:
Both forms of CQ resulted in significant reductions in weight, body fat, total cholesterol, LDL, triglycerides, and fasting blood sugar levels. At the same time, there were significant increases in HDL cholesterol, plasma 5-HT (serotonin), and creatine (a naturally occurring acid in the body that helps supply energy to cells).

Conclusions:
“CQR-300 (300 mg daily) and CORE (1,028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids, thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.”

 

Mechanism of Action

 Cissus quadrangularis may aid in weight loss efforts by raising levels of serotonin and creatine. Previous studies have shown a link between serotonin and weight loss possibly because it improves mood and reduces binge eating. Increases in creatine may support increased lean muscle mass. CQ also inhibits pancreatic lipase (an enzyme that breaks down fat) by 60%, and alpha-amylase and alpha-glucosidase (which break down carbohydrates) by 90% and 39%, respectively.