Celery Seed 3nB Clinical Evidence

Unpublished paper
Venkat S, et al. Use of Ayurvedic medicine in the treatment of rheumatic illness. Department of Orthopaedics, Kovai Medical Center and Hospitals, Coimbatore, India, 1995. 

Topic: 
Can celery seed extract reduce joint pain and increase joint mobility?

Background:
In a preliminary clinical study, 75 mg of phthalides from celery seed taken twice daily for 6-12 weeks was found to significantly reduce the severity of joint pain. Can the results be replicated?

Study Type:
Human clinical intervention trial

Study Design:
Patients took capsules of phthalides (refined from celery seed extract) for 3 weeks

Subjects:
70 patients with rheumatic illness

Dosage:
Two doses of 75 mg daily for 3 weeks

Results:
Subjects were divided into groups based on the duration and intensity of their initial pain: horrible, distressing, discomforting or mild. All groups experienced statistically significant improvements. A full 100% of the patients with “horrible” pain ranked their pain as “distressing” after treatment, 100% of the patients with “distressing” pain dropped to a “discomforting” level of pain, and 81% of those who started with “discomforting” pain ended with “mild” pain. The frequency of pain decreased as well: 88% of the patients with constant pain had only intermittent pain at the end of the trial, while 100% of the patients with intermittent pain had only momentary pain after treatment. In addition, well being increased by an average of 18.2%, and walking mobility increased by 25%. All results were statistically significant. 

 

 

Celery Seed 3nB Mechanism of Action

Celery seed contains phthalides, substances that are thought to be anti-inflammatory agents. They work by inhibiting pro-inflammatory prostaglandins to reduce pain resulting from the body’s inflammatory response to degenerative conditions. (Aspirin and aspirin-like drugs use the same pain-killing mechanism.) Reducing pain and inflammation also has the result of improving joint function.